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1.
An. bras. dermatol ; 84(3): 285-288, jul. 2009. ilus
Article in English, Portuguese | LILACS | ID: lil-521755

ABSTRACT

O pioderma gangrenoso é doença cutânea inflamatória rara, idiopática. Afeta principalmente adultos; apenas cerca de 4 por cento dos casos são diagnosticados em crianças e adolescentes. Existem quatro formas clínicas de pioderma gangrenoso: ulcerativa, pustular, bolhosa e vegetante (pioderma granulomatoso superficial). O pioderma granulomatoso superficial é considerado a forma mais benigna e incomum da doença. Em pacientes submetidos a manipulação cirúrgica, uma eventual manifestação do pioderma gangrenoso ocorre nos locais de intervenção. Relata-se o caso de criança de cinco anos de idade, vítima de queimadura, que apresentou pioderma granulomatoso superficial sobre áreas doadoras de enxertos.


Pyoderma gangrenosum is a rare idiopathic skin disease. It affects mainly adults, and only 4 percent of the cases are diagnosed on children and adolescents. There are four clinical forms of pyoderma gangrenosum: ulcerative, pustular, bullous, and vegetative (superficial granulomatous pyoderma). Superficial granulomatous pyoderma is considered the most benign and uncommon form of the disease. Patients who have undergone surgical procedures may occasionally present pyoderma gangrenosum manifestations on the surgical site. A case of a five-year-old child, victim of burn, who presented superficial granulomatous pyoderma on the skin graft donor sites is reported.


Subject(s)
Child, Preschool , Humans , Male , Pyoderma Gangrenosum/etiology , Skin Transplantation/adverse effects , Burns/surgery , Pyoderma Gangrenosum/classification , Pyoderma Gangrenosum/pathology , Skin Transplantation/pathology
2.
ACM arq. catarin. med ; 36(supl.1): 183-185, jun. 2007. ilus
Article in Portuguese | LILACS | ID: lil-533017

ABSTRACT

Introdução: a cola de fibrina tem sido amplamente utilizada por várias especialidades médicas,principalmente pelas áreas cirúrgicas. Seu uso em enxertos de pele foi descrito em 1944 por Tidrick e Warner2, Apesar de apresentar inúmeras vantagensteóricas, seu uso não é comum no nosso meio. Objetivo: O objetivo do trabalho é demonstrar uma maneirasimplificada de produzir a cola de fibrina oriunda de material autólogo, Sua produção é simples e rápida epara isto se pode dispor de materiais prontamente acessíveis. Conclusão: Pode-se concluir que o uso decola autóloga de fibrina em enxertos de pele é um método adjuvante prático e rápido, com inúmeras vantagensteóricas, A usa produção depende de e materiais simples e facilmente acessíveis.


The fibrin glue has been widely used for some medical specialties, mainly for the surgical areas. Its use in skin grafts was described in 1944 by Tidrick andWarner 2. Despite several theoretical advantages, its use is not common practice. The objective of the work is to demonstrate a simplified way to produce the fibrin glue using the bloodof the patient . Its production is simple and fast and makes use of readily available materials. The use of fibrin glue on skin grafts is a practicaland fast method of securing it. The production utilises simple and easily accessible materials.


Subject(s)
Humans , Burns , Fibrin Tissue Adhesive , Skin Transplantation , Surgery, Plastic , Fibrin Tissue Adhesive/adverse effects , Surgery, Plastic/rehabilitation , Burns/surgery , Burns/pathology , Skin Transplantation/pathology , Skin Transplantation/rehabilitation
3.
The Medical Journal of Malaysia ; : 184-185, 2004.
Article in Malayalam | WPRIM | ID: wpr-629957

ABSTRACT

Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) evaluation were carried out in the in vivo skin construct using fibrin as biomaterial. To investigate its progressive remodeling, nude mice were grafted and the Extracellular Matrix (ECM) components were studied at four and eight weeks post-grafting. It was discovered that by 4 weeks of remodeling the skin construct acquired its native structure.


Subject(s)
Collagen/physiology , Extracellular Matrix/pathology , Fibroblasts/pathology , Mice, Nude , Microscopy, Electron, Scanning , Microscopy, Electron, Transmission , Regeneration/physiology , Skin/pathology , Skin Transplantation/pathology , Tissue Engineering
4.
The Medical Journal of Malaysia ; : 39-40, 2004.
Article in Malayalam | WPRIM | ID: wpr-629923

ABSTRACT

Our objective is to determine the quality of tissue engineered human skin via immunostaining, RT-PCR and electron microscopy (SEM and TEM). Culture-expanded human keratinocytes and fibroblasts were used to construct bilayer tissue-engineered skin. The in vitro skin construct was cultured for 5 days and implanted on the dorsum of athymic mice for 30 days. Immunostaining of the in vivo skin construct appeared positive for monoclonal mouse anti-human cytokeratin, anti-human involucrin and anti-human collagen type I. RT-PCR analysis revealed loss of the expression for keratin type 1, 10 and 5 and re-expression of keratin type 14, the marker for basal keratinocytes cells in normal skin. SEM showed fibroblasts proliferating in the 5 days in vitro skin. TEM of the in vivo skin construct showed an active fibrocyte cell secreting dense collagen fibrils. We have successfully constructed bilayer tissue engineered human skin that has similar features to normal human skin.


Subject(s)
Fibroblasts/cytology , Keratinocytes/cytology , Mice, Nude , Microscopy, Electron , Microscopy, Electron, Scanning , Quality Control , Regeneration/physiology , Skin/pathology , Skin Transplantation/pathology , Skin Transplantation/standards , Tissue Engineering/standards
5.
ACM arq. catarin. med ; 32(supl.1): 7-10, out. 2003. ilus
Article in Portuguese | LILACS | ID: lil-517740

ABSTRACT

A incidência de carcinomas de pele e lábio representa parcela significativa dos procedimentos cirúrgicos reconstrutivos. O presente estudo pretendeu analisar os aspectos epidemiológicos envolvidos e as solu- ções cirúrgicas. Os autores revisaram retrospectivamente os prontuários dos pacientes com tumores da área craniofacial atendidos no Serviço de Cirurgia Plástica do Hospital Ernesto Dornelles, cujas reconstruções se fizeram através de retalhos e enxertos, entre novembro de 2000 e novembro de 2002. Foram avaliados os dados referentes à epidemiologia e o manejo cirúrgico. Dentre os 12 casos estudados, 10 (83,3) eram do sexo masculino. A idade variou entre 56 e 94 anos(média de 76,5 anos). O conhecimento dos fatores epidemiológicos inerentes aos carcinomas de pele e lábio faz-se importante para o reconhecimento do impacto e do modo de ocorrência destas neoplasias em nosso meio.


The incidence of skin and lip carcinomas makes them an important part of the reconstructive surgeries. This paper intented to analyze the epidemiologic aspects and the surgical management. The authors reviewed all cases of skin and lip carcinomas of which flaps and skin grafts were required for reconstructions, attended between november 2000 and november 2002 in the Plastic Surgery Service at Ernesto Dornelles Hospital, Porto Alegre, RS, Brazil. Epidemiologic data and surgical management were analyzed. From 12 cases reviewed 10 (83,3) were masculine. The age changed from 56 to 94 years- old(average 76,5 y/o). Arquivos Catarinenses de Medicina - Volume 32 - Suplemento 01 - 2003 The knowledge of skin and lip carcinomas epidemiology is vital to perceive the importance and impact of this kind of pathology. The understanding of these factors allow adequate patient management and rehabilitation.


Subject(s)
Humans , Male , Female , Middle Aged , Aged, 80 and over , Carcinoma, Basal Cell , Skin Transplantation , Carcinoma, Basal Cell/surgery , Carcinoma, Basal Cell/classification , Carcinoma, Basal Cell/epidemiology , Carcinoma, Basal Cell/pathology , Carcinoma, Basal Cell/prevention & control , Skin Transplantation/pathology
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